How can I diagnose if the 421 error is due to a firewall blocking the SMTP connection?

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Grade: Education Subject: Support
How can I diagnose if the 421 error is due to a firewall blocking the SMTP connection?
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To check for firewall interference, temporarily disable your firewall (or create a rule to allow outgoing connections on port 25, 465, or 587 – the common SMTP ports) and attempt to send an email. If the connection succeeds, your firewall is the culprit. Re-enable the firewall and configure it to permit SMTP traffic.