What are some common file system permission issues that lead to 500.19 errors?

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Grade: Education Subject: Support
What are some common file system permission issues that lead to 500.19 errors?
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Common issues include the application pool identity lacking permissions to access DLLs, configuration files (web.config), or any other files required by the application. Also, ensure the application pool identity has permissions to access the physical path specified in the application's settings in IIS Manager.