Why do I get 'Unhandled Exception' only with a specific application on Windows 10?

If the error occurs only with one specific application, it's highly likely to be an issue with that application rather than a system-wide .NET Framework problem. This could be due to a bug in the application's code, an incomplete or corrupted installation of the application, missing application-specific dependencies, or compatibility issues with your current Windows 10 setup. Reinstalling the application, checking its system requirements, or contacting its developer for support is often the best course of action.