Are there any significant changes to the villains featured in the 'Superior Spider-Man' animated adaptation compared to the comics?

Yes, the animated adaptation often recontextualizes villains to fit the 'Superior' storyline. Some villains are manipulated or enhanced by Otto Octavius to prove his superiority, while others are defeated in more brutal and efficient ways. The focus shifts from traditional hero-villain conflicts to showcasing Otto's strategic brilliance and willingness to cross moral lines. Some villains also receive altered backstories or motivations.